Reaktionsgleichung
[OH:1][CH:2]([CH2:16][OH:17])[CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].[H-].[Na+].F[C:21]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:22]=1[C:23]#[N:24].C1C[O:35]CC1>>[C:23]([C:22]1[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:21]=1[O:17][CH2:16][CH:2]([OH:1])[CH2:3][CH2:4][NH:5][C:13]([C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:6]([OH:35])=[O:15])=[O:14])#[N:24]Komponenten
5
Versuchsvorschrift
2-(3,4-dihydroxybutyl)isoindoline-1,3-dione was reacted as described in Intermediate Y(2) with sodium hydride and 2-fluoro-4-nitrobenzonitrile in THF to get 2-(4-(2-cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid which is used as-is in the next step. LC-MS (M+H)+=400.1.
Quellen und Nachweise
- ORD-Eintrag
- ord-a21c3b254e9a4dbd835dc04487976639
- Quelldatensatz
- uspto-grants-2014_01
- Patentnummer
- US08637523B2
Verknüpfte Notizen
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