Sodium Hydroxide → 8-Fluoro-2-methoxy-4-quinolinecarboxylic acid

HRID 47432Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47432
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([O:16][CH3:17])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[N:8]=[C:7]([O:16][CH3:17])[CH:6]=[C:5]2[C:3]([OH:4])=[O:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 544876468-Fluoro-2-methoxyquinoline-4-carboxylic Acid Methyl Ester

Produkt 1

HCID 227451438-Fluoro-2-methoxy-4-quinolinecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

8-Fluoro-2-methoxyquinoline-4-carboxylic acid methyl ester (0.1 82 g) in methanol (10 ml) containing 2N sodium hydroxide (0.41 ml) was stirred at room temperature for 16 h. Solvent was removed at reduced pressure, dissolved in water, and adjusted to pH2 with 2N hydrochloric acid. The precipitated title compound (0.155 g) was collected by filtration and dried. m/z (API−): 222 (MH+). 1H NMR δ: 4.02 (3H, s), 7.44-7.62 (3H, m), 8.31 (1H, d).

Aufarbeitung

  1. customSolvent was removed at reduced pressure
  2. dissolutiondissolved in water
  3. customThe precipitated title compound (0.155 g)
  4. filtrationwas collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-99e2d3b1335843f0a3515c01d591ba7d
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699879B1

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