HCID 58093434, Verbindung → HCID 178517723, Verbindung

HRID 475001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 475001
C[O:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1>Cl>[CH2:9]([C:7]1[CH:6]=[CH:5][NH:4][C:3](=[O:2])[N:8]=1)[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

3

Edukt 1

HCID 58093434HCID 58093434, Verbindung

Produkt 1

HCID 178517723HCID 178517723, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 2-methoxy-4-phenethylpyrimidine (0.50 g, 2.3 mmol) in concentrated HCl (4.0 mL) was heated under reflux for 16 h. The reaction solution was cooled to room temperature and filtered. The filter cake was washed with water and dried under reduced pressure to give the title compound (0.34 g, 74%) as an off-white solid: 1H NMR (500 MHz, CD3OD) δ 8.52 (d, J=6.5 Hz, 1H), 7.33-7.24 (m, 5H), 6.78 (d, J=6.0 Hz, 1H), 3.12-3.07 (m, 4H).

Aufarbeitung

  1. temperatureunder reflux for 16 h
  2. filtrationfiltered
  3. washThe filter cake was washed with water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ebb1cb2438c042898a0f2eef58fd6b60
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637501B2

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