2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine → HCID 178441566, Verbindung

HRID 47508

Reaktionsgleichung

Reaktionsgleichung von HRID 47508
[OH:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.[NH2:11][C:12]1[C:21]2[N:22]=[C:23]([CH2:28][CH2:29][CH2:30][CH3:31])[N:24]([CH2:25][CH2:26][NH2:27])[C:20]=2[C:19]2[N:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N:13]=1>>[NH2:11][C:12]1[C:21]2[N:22]=[C:23]([CH2:28][CH2:29][CH2:30][CH3:31])[N:24]([CH2:25][CH2:26][NH:27][C:8]([C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([OH:1])[N:7]=3)=[O:10])[C:20]=2[C:19]2[N:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N:13]=1

Komponenten

3

Edukt 2

HCID 219460272-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamineHCID 178524392HCID 178524392, Verbindung

Produkt 1

HCID 178441566HCID 178441566, VerbindungAusbeute 21,8 %

Versuchsvorschrift

Using the general method of Example 97 6-hydroxypicolinic acid (0.24 g, 1.7 mmole) was reacted with 2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine (0.5 g, 1.7 mmol) to provide 0.15 g of N-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-6-hydroxy-2-pyridinecarboxamide as a white powder, m.p. 258-260° C. Analysis: Calculated for C21H23N7O2+½ CH3CN: %C, 62.03; %H, 5.80; %N, 24.66. Found: %C, 61.87; %H, 5.70; %N, 24.60.

Quellen und Nachweise

ORD-Eintrag
ord-e9083d2ce62d487684022ded273cd3d7
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699878B2

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