Iodine → HCID 178509895, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]#[N:12])[C:5]2[CH:6]=[N:7][NH:8][C:9]=2[CH:10]=1.[OH-].[K+].[I:15]I>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]#[N:12])[C:5]2[C:6]([I:15])=[N:7][NH:8][C:9]=2[CH:10]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
To a solution of 6-chloro-1H-indazole-4-carbonitrile (2.0 g, 11.26 mmol) in DMF (30 mL) was added KOH (1.89 g, 33.78 mmol) and I2 (5.72 g, 22.52 mmol). The mixture was heated at 50° C. overnight. The reaction mixture was quenched with EtOAc (200 mL) and water (100 mL). The organic layer was concentrated in vacuo to afford 6-chloro-3-iodo-1H-indazole-4-carbonitrile as white solid (2.01 g, 58.8%). MS (ESI): m/z=304 [M+1]+.
Aufarbeitung
- customThe reaction mixture was quenched with EtOAc (200 mL) and water (100 mL)
- concentrationThe organic layer was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-8433ffb444a643b28a68dbd5f2f2310b
- Quelldatensatz
- uspto-grants-2014_01
- Patentnummer
- US08637537B2
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