2-(1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)propan-2-amine → HCID 178456847, Verbindung
Reaktionsgleichung
O1CCCCC1[N:7]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]([NH2:19])([CH3:18])[CH3:17])=[CH:15][C:10]=2[N:9]=[CH:8]1.Cl[C:21]1[N:26]=[C:25]([NH:27][C:28]2[NH:32][N:31]=[C:30]([CH:33]3[CH2:35][CH2:34]3)[CH:29]=2)[CH:24]=[CH:23][N:22]=1>>[NH:7]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]([NH:19][C:21]3[N:26]=[C:25]([NH:27][C:28]4[CH:29]=[C:30]([CH:33]5[CH2:35][CH2:34]5)[NH:31][N:32]=4)[CH:24]=[CH:23][N:22]=3)([CH3:17])[CH3:18])=[CH:15][C:10]=2[N:9]=[CH:8]1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 140 °C
Versuchsvorschrift
A neat mixture of 94 (691 mg, 2.67 mmol) and 53 (210 mg, 0.89 mmol) was stirred under nitrogen at 140° C. for 18 h. The dark brown mixture was cooled to RT and was purified by preparative HPLC to afford 25 mg (7.5%) of I-17 as white solid.
Aufarbeitung
- temperatureThe dark brown mixture was cooled to RT