HCID 58403540, Verbindung → (3-methyl-1H-indol-4-yl)methanamine

HRID 475268Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 475268
[CH3:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[NH:4][CH:3]=1>N.CO.[Ni]>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH2:11][NH2:12])[NH:4][CH:3]=1

Komponenten

5

Edukt 1

HCID 58403540HCID 58403540, Verbindung

Produkt 1

HCID 83815702(3-methyl-1H-indol-4-yl)methanamineAusbeute 97,5 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 232 (200 mg, 1.28 mmol) in 7 N NH3 in MeOH (10 mL) was added Raney nickel (20 mg) and the solution was stirred under hydrogen (1 atm.) at RT overnight. The dark mixture was filtered and the filtrate was concentrated under reduced pressure to afford 200 mg (91%) (3-methyl-1H-indol-4-yl)methanamine (234) as white solid: MS (ESI) m/z=144.3 [M−16]+.

Aufarbeitung

  1. filtrationThe dark mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f8a1291dc47249ef90b568a104b0f5a9
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637537B2

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