Methyl iodide → 1-[1-(1-ethoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

HRID 47528Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47528
[CH2:1](Br)C#C.CI.COC(N1CCC(N2CCC(N3C4C=CC=CC=4NC3=O)CC2)CC1)=O.[CH2:33]([O:35][C:36]([N:38]1[CH2:43][CH2:42][CH:41]([N:44]2[CH2:49][CH2:48][CH:47]([N:50]3[C:54]4[CH:55]=[CH:56][CH:57]=[CH:58][C:53]=4[NH:52][C:51]3=[O:59])[CH2:46][CH2:45]2)[CH2:40][CH2:39]1)=[O:37])[CH3:34]>>[CH2:33]([O:35][C:36]([N:38]1[CH2:43][CH2:42][CH:41]([N:44]2[CH2:45][CH2:46][CH:47]([N:50]3[C:54]4[CH:55]=[CH:56][CH:57]=[CH:58][C:53]=4[N:52]([CH3:1])[C:51]3=[O:59])[CH2:48][CH2:49]2)[CH2:40][CH2:39]1)=[O:37])[CH3:34]

Komponenten

5

Edukt 4

HCID 6328Methyl iodideHCID 7842Propargyl bromideHCID 227452181-[1-(1-methoxycarbonylpiperidin-4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-oneHCID 22745278HCID 22745278, Verbindung

Produkt 1

HCID 98649961-[1-(1-ethoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Versuchsvorschrift

Example 1 was repeated except that the propargyl bromide was replaced with methyl iodide and 1-[1-(1-methoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one was replaced with 1-[1-(1-ethoxycarbonylpiperidin-4-yl-piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one which was synthesized by the method of Referential Example 16, and the title compound was obtained as a colorless oil.

Aufarbeitung

  1. customwas synthesized by the method of Referential Example 16

Quellen und Nachweise

ORD-Eintrag
ord-3a6f96770b774be6b65c81ddcc0f583e
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699880B1

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