6-cyclopropyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid → HCID 56597432, Verbindung

HRID 475964Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 475964
[CH3:1][CH:2]([N:4]1[C:8]2[N:9]=[C:10]([CH:16]3[CH2:18][CH2:17]3)[CH:11]=[C:12]([C:13]([OH:15])=O)[C:7]=2[CH:6]=[N:5]1)[CH3:3].[NH2:19][CH2:20][C:21]1[C:22](=[O:34])[NH:23][C:24]([CH3:33])=[CH:25][C:26]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH:16]1([C:10]2[CH:11]=[C:12]([C:13]([NH:19][CH2:20][C:21]3[C:22](=[O:34])[NH:23][C:24]([CH3:33])=[CH:25][C:26]=3[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:15])[C:7]3[CH:6]=[N:5][N:4]([CH:2]([CH3:1])[CH3:3])[C:8]=3[N:9]=2)[CH2:18][CH2:17]1

Komponenten

3

Edukt 2

HCID 25259926-cyclopropyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidHCID 671242923-(Aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone

Produkt 1

HCID 56597432HCID 56597432, Verbindung

Versuchsvorschrift

The title compound was prepared in the same manner as described in example 11 from 1-(1-methylethyl)-6-(cyclopropyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (150 mg, 0.612 mmol) and 3-(aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone (153 mg, 0.612 mmol). The product was collected as a white solid, 0.067 g (24%). LCMS E-S (M+H)=442.3. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.04-1.11 (m, 3H), 1.47 (d, J=6.57 Hz, 5H), 2.22 (s, 3H), 2.24-2.29 (m, 1H), 3.17 (d, J=5.31 Hz, 2H), 4.07-4.15 (m, 1H), 4.19 (d, J=4.29 Hz, 2H), 5.06-5.18 (m, 1H), 6.01 (s, 1H), 7.36 (s, 1H), 7.38-7.49 (m, 5H), 8.18 (s, 1H), 8.70 (s, 1H), 11.88 (s, 1H).

Aufarbeitung

  1. customThe product was collected as a white solid, 0.067 g (24%)

Quellen und Nachweise

ORD-Eintrag
ord-a20c7cdc521742408591ed906c26b9e2
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637509B2

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