Methoxyphenylacetic acid → {(7R)-7-[(2-Methoxy-2-phenyl-acetyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl}-acetic acid

HRID 476261

Reaktionsgleichung

[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=O.[CH3:13][NH:14][C@H:15]1[CH2:34][N:19]2[C:20]3[C:25]([C:26]([CH2:27][C:28]([O:30]CCC)=[O:29])=[C:18]2[CH2:17][CH2:16]1)=[CH:24][CH:23]=[CH:22][CH:21]=3>>[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([N:14]([CH3:13])[C@H:15]1[CH2:34][N:19]2[C:20]3[C:25]([C:26]([CH2:27][C:28]([OH:30])=[O:29])=[C:18]2[CH2:17][CH2:16]1)=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:6]

Komponenten

Edukt 2

HCID 107202Methoxyphenylacetic acid

HCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Produkt 1

HCID 58349689{(7R)-7-[(2-Methoxy-2-phenyl-acetyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl}-acetic acid

Versuchsvorschrift

The title compound was prepared using analogous procedures described in Example 1 (Method A) from methoxy(phenyl)acetic acid and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 407.

Quellen und Nachweise

ORD-Eintrag: ord-3ef258c40ec343c39ec25f53025398a6
Quelldatensatz: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08637671B2

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