Methanol → Methyl 2-fluoro-4-methylbenzoate
Reaktionsgleichung
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12]O>>[CH3:12][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([CH3:11])=[CH:10][C:2]=1[F:1]Komponenten
3
Versuchsvorschrift
2-Fluoro-4-methylbenzoic acid (30.0 g, 195 mmol) was dissolved in MeOH (600 mL, 10 mol), and 12 M HCl (3.2 mL, 39 mmol) was added. The mixture was heated to reflux and stirred for 48 hours, then cooled and concentrated. The recovered material was dried in vacuo for 24 hours to obtain Intermediate (6a) as a white solid that was used without further purification.
Aufarbeitung
- temperatureThe mixture was heated
- temperatureto reflux
- temperaturecooled
- concentrationconcentrated
- customThe recovered material was dried in vacuo for 24 hours
Quellen und Nachweise
- ORD-Eintrag
- ord-de11b31c9e924d26bc575932cd588fc0
- Quelldatensatz
- uspto-grants-2014_01
- Patentnummer
- US08637676B2
Notizen zur Reaktion
Wird geladen…