Phosphorus oxychloride → 3-(Trifluoromethyl)phenylmethanesulfonyl chloride

HRID 476518

Reaktionsgleichung

Reaktionsgleichung von HRID 476518
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7]([O-])(=[O:9])=[O:8].[Na+].P(Cl)(Cl)([Cl:19])=O>>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7]([Cl:19])(=[O:9])=[O:8]

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 23700704Sodium 3-trifluoromethylbenzylsulfonate

Produkt 1

HCID 27946463-(Trifluoromethyl)phenylmethanesulfonyl chlorideAusbeute 90,2 %

Versuchsvorschrift

10 g of sodium 3-trifluoromethylbenzylsulfonate was slowly added to 17.7 ml (29.1 g) of phosphorous oxychloride. The resulting slurry was stirred at 100° to 105° C. for five hours. The reaction mixture was then cooled and filtered. The filter cake was washed with methylene chloride, the washings were combined with the filtrate and then evaporated to dryness affording 8.9 g of 3-trifluoromethylbenzylsulfonyl chloride.

Aufarbeitung

  1. temperatureThe reaction mixture was then cooled
  2. filtrationfiltered
  3. washThe filter cake was washed with methylene chloride
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-51a77baf777e493a98ac7c412476fd90
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04885027

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