1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

HRID 476561

Reaktionsgleichung

Reaktionsgleichung von HRID 476561
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[Ni].C(O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 28651491-Acetyl-4-(4-nitrophenyl)piperazine

Produkt 1

HCID 7362691-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 4-acetyl-1-(4-nitrophenyl)piperazine [C. A., 67, P101031Z] (30 g, 0.12 mole) and Raney nickel (2.5 g) in ethanol (500 ml) was hydrogenated at 60 psi (414 kPa) and 40° for 6 hours followed by 18 hours at room temperature. The catalyst was subsequently removed by filtration, the solvent removed under reduced pressure and the residue crystallized from ethyl acetate to yield the title compound, m.p. 129°-130° (18.4 g, 71%), which was used directly in the next stage.

Aufarbeitung

  1. customThe catalyst was subsequently removed by filtration
  2. customthe solvent removed under reduced pressure
  3. customthe residue crystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-48c587c122724d43b4582d3b03fd9db0
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04885294

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