Ethanol → HCID 53702167, Verbindung

HRID 476586Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 476586
C[C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH:4]=[CH:5][C:6]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[C:9]=1[CH3:25])=[O:7].[F:30]C1C=CC=CC=1C=O.C(O)C.[OH-].[K+]>C(OCC)(=O)C>[F:30][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH:4]=[CH:5][C:6]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[C:9]=1[CH3:25])=[O:7]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 67970o-FluorobenzaldehydeHCID 53923408HCID 53923408, Verbindung

Produkt 1

HCID 53702167HCID 53702167, VerbindungAusbeute 54 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Following a procedure similar to that described in Example 20A above, 14.75 g. (0.0516 mole) of 3-acetyl-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole (Example 20A) was reacted with 2-fluorobenzaldehyde in 260 ml. of ethanol in the presence of 3.44 g. (0.061 mole) of potassium hydroxide pellets and the product, in the form of the free base, recrystallized from ethyl acetate to give 10.0 g (54%) of 3-(2-fluorocinnamoyl)-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole, m.p. 113°-116° C.

Quellen und Nachweise

ORD-Eintrag
ord-4f90ef48f5204388b4dea4355249eba3
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04885295

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