Sodium hydride → N-(2-Pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]-5,6-dimethoxybenzimidazole-2-carboxamide

HRID 476898

Reaktionsgleichung

Reaktionsgleichung von HRID 476898
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[NH:11][C:12]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:13]=2[N:14]=1)=[O:9].[H-].[Na+].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:41]=[CH:42][C:43]=1[O:44][CH3:45])[C:30]([N:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39]Cl)[CH2:34][CH2:33]1)=[O:31]>CS(C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[N:11]([CH2:39][CH2:38][N:35]2[CH2:36][CH2:37][N:32]([C:30](=[O:31])[C:29]3[CH:41]=[CH:42][C:43]([O:44][CH3:45])=[C:27]([O:26][CH3:25])[CH:28]=3)[CH2:33][CH2:34]2)[C:12]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:13]=2[N:14]=1)=[O:9]

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 118091532-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]ethyl chlorideHCID 19837066N-(2-pyridyl)-5,6-dimethoxybenzimidazole-2-carboxamide

Produkt 1

HCID 14371293N-(2-Pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]-5,6-dimethoxybenzimidazole-2-carboxamideAusbeute 44 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel2×

Versuchsvorschrift

In an argon atmosphere, N-(2-pyridyl)-5,6-dimethoxybenzimidazole-2-carboxamide (0.85 g) was dissolved in DMSO (15 ml), and 60% sodium hydride (0.16 g) was added and stirred at room temperature for 1 hr. A solution (5 ml) of 2-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]ethyl chloride (1.25 g) in DMSO was added dropwise and allowed to react overnight at room temperature under agitation. After-treatment and purification in the same manner as described in Example 14 gave the title compound (0.72 g) as amorphous solid.

Aufarbeitung

  1. customto react overnight at room temperature under agitation
  2. customAfter-treatment and purification in the same manner

Quellen und Nachweise

ORD-Eintrag
ord-2f436732b9d94704a5febb0c7011db82
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04886803

Verknüpfte Notizen

Wird geladen…