Phosphorus oxychloride → HCID 70352765, Verbindung

HRID 476912

Reaktionsgleichung

Reaktionsgleichung von HRID 476912
[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[CH:3]=1.P(Cl)(Cl)([Cl:14])=O>CN(C)C=O>[ClH:14].[NH:1]=[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]1=[CH:4][N:5]([CH3:10])[CH3:6]

Komponenten

4

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 811526-Amino-1,3-dimethyluracil

Produkt 1

HCID 70352765HCID 70352765, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

20 g (129 mmol) of 6-amino-1,3-dimethyluracil was suspended in 550 ml of dimethylformamide. 216 g of phosphorus oxychloride was added to the suspension at a temperature below 20° C., and the reaction mixture was stirred for 30 minutes. The resulting precipitate was filtered off and washed with acetone to give 6-imino-1,3-dimethyl-5-dimethylaminomethylene-5,6-dihydrouracil hydrochloride (compound 1) in a 95% yield. The product may also be used in the following reaction without further purification.

Aufarbeitung

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with acetone

Quellen und Nachweise

ORD-Eintrag
ord-c00c826eb76b43c4a2dcc754487c2286
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04886807

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