Sodium Hydroxide → 2-(2-Trifluoromethyl-thiazol-4-yl)ethylene oxide
Reaktionsgleichung
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:11])[CH2:9]Br)[N:7]=1.[OH-].[Na+]>>[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]2[O:11][CH2:9]2)[N:7]=1Komponenten
3
Versuchsvorschrift
5 g (0.018 mol) of 1-(2-Trifluoromethyl-thiazol-4-yl)-1-hydroxy-2-bromoethane are suspended in 4 ml of 50% strength sodium hydroxide solution and stirred for 5 minutes. The mixture is then diluted with ice-water and extracted by shaking with methylene chloride. The organic phase is dried over sodium sulphate and concentrated in vacuo at 20° C., and the resulting oil is purified on a silica gel column using methylene chloride as eluant.
Aufarbeitung
- extractionextracted
- stirringby shaking with methylene chloride
- dry with materialThe organic phase is dried over sodium sulphate
- concentrationconcentrated in vacuo at 20° C.
- customthe resulting oil is purified on a silica gel column
Quellen und Nachweise
- ORD-Eintrag
- ord-6acb9b42941e4d3e8a47593b04865ac5
- Quelldatensatz
- uspto-grants-1989_12
- Patentnummer
- US04886814
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