Potassium Hydroxide → 99517-24-5

HRID 477487Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 477487
[C:1]([C:5]1[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=[C:7]([Cl:14])[CH:6]=1)([O:3]C)=[O:2].[OH-].[K+]>CO>[Cl:14][C:7]1[CH:6]=[C:5]([C:1]([OH:3])=[O:2])[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 14838646HCID 14838646, Verbindung

Produkt 1

HCID 1483864799517-24-5Ausbeute 94,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 7-carbomethoxy-5-chlorobenzo[b]furan (6c) (3.02 g, 14.3 mmol) containing potassium hydroxide (3.22 g) in 100 ml of aqueous methanol (CH3OH/H2O=3/2) was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was acidified with conc. HCl to pH of about 1, cooled in freezer for several hours and filtered to give 7c as an off-white solid (2.65 g, 94.3%), mp 212°-215° C. NMR (DMSO-d6) δ 8.0-6.87 (m, 5H, aromatic protons and OH).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. temperaturecooled in freezer for several hours
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-09ade81416fd4b5f8adc751812ca7058
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04888353

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