Dimethylformamide → HCID 178499052, Verbindung

Reaktionsgleichung

C[C:2]([CH2:4][C:5]([O:7]CC)=O)=[S:3].[NH2:10][C:11]1[N:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[NH:13][N:12]=1.[CH3:20]N(C)C=O>>[OH:7][C:5]1[CH:4]=[C:2]([S:3][CH3:20])[N:12]2[N:13]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[N:15]=[C:11]2[N:10]=1

Komponenten

Edukt 3

HCID 6228Dimethylformamide

HCID 77201methyl 5-amino-1H-(1,2,4)triazole-3-carboxylate

HCID 11744773Butanoic acid, 3-thioxo-, ethyl ester

Produkt 1

HCID 178499052HCID 178499052, Verbindung

Versuchsvorschrift

A suspension of ethyl 2-methylthiocarbonylacetate (37.6 g) an 3-amino-5-methoxycarbonyl-s-triazole (20 g) in dimethylformamide (200 ml) was refluxed for one hour. After removing the solvent by distillation under reduced pressure, ether was added to the residue, and the formed crystals were purified by silica gel chromatography, giving 11.7 g of the objective compound.