Benzyl Chloride → 5-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

HRID 477732

Reaktionsgleichung

Reaktionsgleichung von HRID 477732
[NH2:1][C:2]1[N:6]=[C:5]([SH:7])[NH:4][N:3]=1.[OH-].[Na+].[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:1][C:2]1[NH:3][N:4]=[C:5]([S:7][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:6]=1

Komponenten

5

Edukt 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 1785092965-amino-1H-1,2,4-triazole-3-thiol

Produkt 1

HCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amineAusbeute 90,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3-Amino-5-mercapto-1,2,4-triazole (40.36 g) was treated at room temperature with sodium hydroxide (13.9 g) in ethanol (450 ml), and benzyl chloride (44.3 g) was added. The mixture was stirred overnight, and was then filtered. The ethanol was evaporated off, and the residue was recrystallised from ethyl acetate to give 64.97 g of the desired product, mp 104° C.

Aufarbeitung

  1. additionwas added
  2. filtrationwas then filtered
  3. customThe ethanol was evaporated off
  4. customthe residue was recrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-b82cfc36a6374223bdd0d890c06b2c86
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04889553

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