N-bromobutanimide → Ethyl 2-(bromomethyl)-3-fluorobenzoate

HRID 477786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 477786
[F:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[Br:14]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:3]([CH2:13][Br:14])=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 14626272Ethyl 3-fluoro-2-methylbenzoate

Produkt 1

HCID 14626273Ethyl 2-(bromomethyl)-3-fluorobenzoateAusbeute 82,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

To a solution of 11 g of ethyl 3-fluoro-2-methylbenzoate in 300 ml of carbon tetrachloride is added 12 g of N-bromosuccinimide and the mixture is refluxed with heating for 12 hours. After cooling, the mixture is washed with water and a saturated saline solution and dried over magnesium sulfate and the solvent is distilled off under reduced pressure to give 13 g of ethyl 3-fluoro-2-bromomethylbenzoate. Mass spectrum m/z: 262, 260(M+).

Aufarbeitung

  1. temperaturethe mixture is refluxed
  2. temperaturewith heating for 12 hours
  3. temperatureAfter cooling
  4. washthe mixture is washed with water
  5. dry with materiala saturated saline solution and dried over magnesium sulfate
  6. distillationthe solvent is distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-44272f909ca047aca1e56cdfa6c427f5
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04889858

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