1,1'-Carbonyldiimidazole → 2-(4-chlorophenyl)-6-methoxy-2H-1,2,4-benzothiadiazine-3(4H)-one 1,1-dioxide
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[S:10]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)(=[O:12])=[O:11].[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22]>O1CCOCC1>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([N:13]2[C:21](=[O:22])[NH:1][C:2]3[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=3[S:10]2(=[O:12])=[O:11])=[CH:15][CH:16]=1Komponenten
4
Versuchsvorschrift
A mixture of 2-amino-4-methoxy-N-(4-chlorophenyl)-benzenesulfonamide (24.37 g) and 1,1'-carbonyldiimidazole (18.93 g) in dried dioxane (500 ml) was refluxed overnight and then concentrated to dryness. The residue was washed with methanol and collected by filtration to yield 2-(4-chlorophenyl)-6-methoxy-2H-1,2,4-benzothiadiazine-3(4H)-one 1,1-dioxide (23.9 g).