methyl 8-oxo-9-phenyl-8H-pyrido[1,2-d]thieno[2,3-f][1,4]thiazepin-11-carboxylate → methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate

HRID 477945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 477945
[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9]S[C:11]3[CH:15]=[CH:14][S:13][C:12]=3[C:6]2=[C:5]([C:16]([O:18][CH3:19])=[O:17])[CH:4]=[C:3]1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C(C)=CC=CC=1>[O:1]=[C:2]1[C:3]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:4][C:5]([C:16]([O:18][CH3:19])=[O:17])=[C:6]2[N:7]1[CH:8]=[CH:9][C:11]1[CH:15]=[CH:14][S:13][C:12]=12

Komponenten

3

Edukt 1

HCID 14666703methyl 8-oxo-9-phenyl-8H-pyrido[1,2-d]thieno[2,3-f][1,4]thiazepin-11-carboxylate

Produkt 1

HCID 14666705methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

4.4 g of methyl 8-oxo-9-phenyl-8H-pyrido[1,2-d]thieno[2,3-f][1,4]thiazepine-11-carboxylate were heated under reflux and under argon together with 90 ml of xylene until the reaction was completed. The solution was evaporated in vacuo and the residue was treated with 100 ml of n-hexane, whereupon the product was removed by filtration. By recrystallization from ethyl acetate, there was obtained methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate as yellow crystals of m.p. 153°-156°.

Aufarbeitung

  1. customThe solution was evaporated in vacuo
  2. additionthe residue was treated with 100 ml of n-hexane, whereupon the product
  3. customwas removed by filtration
  4. customBy recrystallization from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-de7c74879ba14bd0b443914240e9938f
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04889848

Notizen zur Reaktion

Wird geladen…