Thionyl Chloride → HCID 178509760, Verbindung

HRID 477971

Reaktionsgleichung

Reaktionsgleichung von HRID 477971
C([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14](O)[CH2:15][CH2:16][CH2:17][C:18]2[N:19]=[CH:20][N:21]([Si](C)(C)C)[CH:22]=2)=[CH:10][CH:9]=1)=O)(C)(C)C.S(Cl)([Cl:30])=O>>[Cl:30][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:6]#[N:5])=[CH:9][CH:10]=1)[CH2:15][CH2:16][CH2:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 199304194-[4-(p-tert-Butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole

Produkt 1

HCID 178509760HCID 178509760, Verbindung

Versuchsvorschrift

A solution of 4.5 g of 4-[4-(p-tert-butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole in 50 ml of thionyl chloride is refluxed for 1 h, cooled and evaporated. The residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution. The organic phase is separated, dried over sodium sulfate and evaporated to yield the title compound (c).

Aufarbeitung

  1. temperaturecooled
  2. customevaporated
  3. customThe residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution
  4. customThe organic phase is separated
  5. dry with materialdried over sodium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5fbd31894475459982e5655955531d5c
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04889861

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