Sodium Hydroxide → Regadenoson Impurity 1

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Hydroxide	HCID 14798	—
Edukt	Ethyl 1-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylate	HCID 9865974	—
Produkt	Regadenoson Impurity 1	HCID 9864495	—

Reaktionsschritte

Compound 12 (0.05 mg, 0.12 mmol) was dissolved one equivalent of 1N NaOH. The solution was allowed to stir at Rt for 2 h, then acidified to pH 4. The resulting precipitate was filtered and washed with water and ether. 1HNMR (CD3OD) Δ3.75 (m, 1H), 3.90 (m, 1H), 4.13 (d, 1H), 4.43 (d, 1H), 4.64 (m, 1H), 6.05 (d, 1H), 8.10 (s, 1H), 8.35 (s, 1H), 9.05 (s, 1H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06642210B1
Quelldatensatz	uspto-grants-2003_11
ORD ID	ord-01f2e29ea735443e91455d50491d6891
Quellennotiz	uspto-grants-2003_11