(4-Fluoro-3-iodophenyl)methanol → 4-Fluoro-3-iodobenzaldehyde

HRID 478277Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 478277
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[I:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[I:10]

Komponenten

4

Edukt 1

HCID 23497488(4-Fluoro-3-iodophenyl)methanol

Produkt 1

HCID 103080734-Fluoro-3-iodobenzaldehydeAusbeute 29,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysator2×HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The product from Example 30B (6.4 g, 26 mmol) in chloroform (300 mL) was treated with manganese dioxide (4.5 g, 50 mmol), stirred overnight, treated with an additional portion of manganese dioxide (2.25 g), stirred overnight, filtered and concentrated. The residue was purified by flash chromatography over silica gel (ethyl acetate/hexane 1:4) to provide 1.9 g of the title compound.

Aufarbeitung

  1. stirringstirred overnight
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe residue was purified by flash chromatography over silica gel (ethyl acetate/hexane 1:4)

Quellen und Nachweise

ORD-Eintrag
ord-ceb960621f224c55bfbede30bda91587
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642222B2

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