Ammonia → 5-amino-2,2-dimethyl-2H-pyran-3(6H)-one

HRID 478295Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 478295
[CH3:1][C:2]1([CH3:10])[C:7](=[O:8])[CH2:6][C:5](=O)[CH2:4][O:3]1.S(=O)(=O)(O)O.[NH3:16]>C(O)C>[NH2:16][C:5]1[CH2:4][O:3][C:2]([CH3:10])([CH3:1])[C:7](=[O:8])[CH:6]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 140728872,2-dimethyl-2H-pyran-3,5(4H,6H)-dione

Produkt 1

HCID 180009685-amino-2,2-dimethyl-2H-pyran-3(6H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

The product from Example 66C (1.5 g, 11 mmol) in ethanol (40 mL) was treated with concentrated sulfuric acid (0.4 mL), refluxed for 4 hours, cooled to ambient temperature, treated with 2M ammonia in ethanol (50 mL), stirred at ambient temperature for 16 hours and concentrated. The residue was purified by chromatography on silica gel eluting with 10% methanol in dichloromethane to provide the title compound (1.0 g).

Aufarbeitung

  1. temperaturerefluxed for 4 hours
  2. concentrationconcentrated
  3. customThe residue was purified by chromatography on silica gel eluting with 10% methanol in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-2ea5371c5e80499090bfc097ba137d65
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642222B2

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