HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | N-(6-chloro-7H-purin-2-yl)acetamide | HCID 6098997 | — |
| Edukt | 2,3,5-tri-O-acetyl-beta-D-ribofuranosylpurine | HCID 69884339 | — |
| Katalysator | Mercurous Chloride | HCID 24182 | — |
| Produkt | 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine | HCID 14284102 | — |
Reaktionsschritte
The chloromercury derivative of 2-acetamido-6-chloropurine is condensed with 2,3,5-tri-O-acetyl-β-D-ribofuranosylpurine utilizing the method of Lee et. al. (1971), J. Med. Chem., 14:819. The condensation product was treated with ammonia to yield 2-amino-6-chloro-9-(β-D-xylofuranosyl)purine. Further treatment with sodium hydroxyethylmercaptide gives the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06699979B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-74a047b8ea1341e7b4eb239573c52d34 |
| Quellennotiz | uspto-grants-2004_03 |