HCID 53406803, Verbindung → Methyl 4-(piperazin-1-yl)benzoate

HRID 478635

Reaktionsgleichung

Reaktionsgleichung von HRID 478635
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13](CC3C=CC=CC=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[H][H]>CO.[Pd].C>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 53406803HCID 53406803, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 15429161Methyl 4-(piperazin-1-yl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14818447PalladiumcarbonKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-(4-Benzyl-piperazin-1-yl)-benzoic acid methyl ester (19.4 mmol) is dissolved in methanol (150 ml) and Pd/charcoal is added (0.6 g). The mixture is stirred in a hydrogen atmosphere until consumption has ceased. The catalyst is filtered off and the filtrate evaporated. The residue is suspended in diethylether/pentane and the solid filtered of and dried (vacuum). A powder with mp. 95-97° C. is obtained.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate evaporated
  3. filtrationthe solid filtered of and
  4. customdried (vacuum)
  5. customA powder with mp. 95-97° C. is obtained

Quellen und Nachweise

ORD-Eintrag
ord-305fc93190cc47c78bc1b9788ef9a944
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642239B2

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