Pyridine → HCID 11608128, Verbindung

HRID 478639Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 478639
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:19](=[O:21])[CH3:20])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 698734-Phenylpiperidine

Produkt 1

HCID 11608128HCID 11608128, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

4-Phenylpiperidine (87 mmol) and pyridine (96 mmol) are dissolved in dry CH2Cl2 (100 ml) and acetylchloride (96 mmol) in CH2Cl2 (40 ml) is added dropwise to the stirred solution at 10° C. The reaction is stirred for 1 hour at rt. The mixture is extracted three times with water and the water phase is extracted again with CH2Cl2. The combined organic phases are dried over sodium sulfate and evaporated. A pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained.

Aufarbeitung

  1. extractionThe mixture is extracted three times with water
  2. extractionthe water phase is extracted again with CH2Cl2
  3. dry with materialThe combined organic phases are dried over sodium sulfate
  4. customevaporated
  5. customA pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained

Quellen und Nachweise

ORD-Eintrag
ord-ca110666b0384f00a99ffea359f5cb59
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642239B2

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