Hydrochloric Acid → 3-(3-Methylindan-1-ylidene)-1,3-dihydroindol-2-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 0.5 g of 3-methyl-1-indanone, 1.37 g oxindole and 5 ml piperidine in 3 ml of dimethylforamide was heated in a sealed tube at 130° C. overnight to yield a reddish-brown suspension. The mixture was added to 1N hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried with magnesium sulfate and concentrated. Chromatography afforded 120 mg of 3-(3-methylindan-1-ylidene)-1,3-dihydroindol-2-one as an orange solid.

Herkunft & Nachweise