Phenylacetic Acid → 2-(phenylacetamido)butyric Acid Iso-butyl Ester

HRID 478807

Reaktionsgleichung

Reaktionsgleichung von HRID 478807
[C:1]1([CH2:7][C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][CH:12]([CH2:20][CH3:21])[C:13]([O:15][CH2:16][CH:17]([CH3:19])[CH3:18])=[O:14]>>[CH2:16]([O:15][C:13](=[O:14])[CH:12]([NH:11][C:8](=[O:10])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH2:20][CH3:21])[CH:17]([CH3:18])[CH3:19]

Komponenten

3

Edukt 2

HCID 999Phenylacetic AcidHCID 13743360Isobutyl 2-aminobutyrate

Produkt 1

HCID 541767772-(phenylacetamido)butyric Acid Iso-butyl Ester

Versuchsvorschrift

Following General Procedure H above and using phenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by chromatography on silica gel using 9:1 toluene:EtOAc as the eluant.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification

Quellen und Nachweise

ORD-Eintrag
ord-d5ee7a4e057d4912a1772d99eebcd1e1
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642261B2

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