Triphenylphosphine → HCID 69924505, Verbindung

HRID 478965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 478965
[CH2:1]([O:3][C:4](=[O:26])[CH:5]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=1)[C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH3:14])[CH:9]=[C:8]([OH:15])[C:7]=1[F:16])[CH3:2].[C:27]([O:31][C:32]([N:34]1[CH2:39][CH2:38][CH:37]([CH2:40][CH2:41]O)[CH2:36][CH2:35]1)=[O:33])([CH3:30])([CH3:29])[CH3:28].N(C(OCC)=O)=NC(OCC)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[C:27]([O:31][C:32]([N:34]1[CH2:39][CH2:38][CH:37]([CH2:40][CH2:41][O:15][C:8]2[CH:9]=[C:10]([O:12][CH2:13][CH3:14])[CH:11]=[C:6]([CH:5]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=3)[C:4]([O:3][CH2:1][CH3:2])=[O:26])[C:7]=2[F:16])[CH2:36][CH2:35]1)=[O:33])([CH3:30])([CH3:29])[CH3:28]

Komponenten

5

Edukt 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 8541401-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidineHCID 69924374(RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester

Produkt 1

HCID 69924505HCID 69924505, Verbindung

Versuchsvorschrift

In analogy to example 1.5, (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester described in example 1.4 was reacted with 4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester, diethyl azodicarboxylate and triphenylphosphine to give (RS)-4-(2-{3-[(4-cyano-phenylamino)-ethoxycarbonyl-methyl]-5-ethoxy-2-fluoro-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester as a colorless solid. MS: 570.2 ([M+H]+).

Quellen und Nachweise

ORD-Eintrag
ord-affb54998e6242a2935cb1dcfbaecc92
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642386B2

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