Reaktionsgleichung
C([O:3][C:4](=[O:33])/[C:5](/[O:30][CH2:31][CH3:32])=[CH:6]/[C:7]1[CH:12]=[C:11]([CH3:13])[C:10]([O:14][CH2:15][CH2:16][C:17]2[N:18]=[C:19]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[O:20][C:21]=2[CH3:22])=[C:9]([CH3:29])[CH:8]=1)C.CC1C=C(C=C(C)C=1OCCC1N=C(C2C=CC=CC=2)OC=1C)C=O.[Cl-].C(OC([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C(OCC)=O)C>>[CH3:13][C:11]1[CH:12]=[C:7](/[CH:6]=[C:5](\[O:30][CH2:31][CH3:32])/[C:4]([OH:33])=[O:3])[CH:8]=[C:9]([CH3:29])[C:10]=1[O:14][CH2:15][CH2:16][C:17]1[N:18]=[C:19]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[O:20][C:21]=1[CH3:22]Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
In analogy to the procedure described in example 120 f], 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid ethyl ester {prepared from 3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzaldehyde (example 117) and (ethoxy-ethoxycarbonyl-methyl)-triphenyl-phosphonium chloride (K. K. Bach, H. R. El-Seedi, H. M. Jensen, H. B. Nielsen, I. Thomson, K. B. G. Torssell, Tetrahedron 1994, 50, 7543-7556) in analogy to the procedure described in example 114 c]} was saponified to yield 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid as colorless crystals.
Quellen und Nachweise
- ORD-Eintrag
- ord-b362b31a68d54496a120591d5e9e9028
- Quelldatensatz
- uspto-grants-2003_11
- Patentnummer
- US06642389B2
Verknüpfte Notizen
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