2-Bromo-4'-(trifluoromethyl)acetophenone → 2-Hydroxy-1-[4-(trifluoromethyl)phenyl]ethan-1-one

HRID 47932

Reaktionsgleichung

Reaktionsgleichung von HRID 47932
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:16].[Na+]>CO>[OH:16][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 2723810Sodium Formate

Produkt 1

HCID 112871692-Hydroxy-1-[4-(trifluoromethyl)phenyl]ethan-1-oneAusbeute 80,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux
  3. concentrationThe reaction mixture was concentrated
  4. additionpoured into water (500 mL)
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water
  7. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-4e10606f65fc4c4ab3290ea0ed22b311
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699995B1

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