Potassium cyanate → 4-methyl-N-(2,2,2-trichloro-1-isocyanatoethyl)benzamide

HRID 479496Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 479496
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9](Cl)[C:10]([Cl:13])([Cl:12])[Cl:11])=[O:7])=[CH:4][CH:3]=1.[O-:17][C:18]#[N:19].[K+]>CC(C)=O>[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]([N:19]=[C:18]=[O:17])[C:10]([Cl:13])([Cl:12])[Cl:11])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 11378442Potassium cyanateHCID 123415764-Methyl-N-(1,2,2,2-tetrachloroethyl)benzamide

Produkt 1

HCID 187707404-methyl-N-(2,2,2-trichloro-1-isocyanatoethyl)benzamideAusbeute 60,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A stirred solution of Example 37D (1.00 g, 3.32.00 mmol) in acetone (20 mL) at ambient temperature was treated with potassium cyanate (1.60 g, 16.0 mmol). The reaction mixture was stirred for 12 hours, concentrated, and the crude residue was purified by flash chromatography (elution with 50% ethyl acetate/hexanes) to provide 620 mg of the desired product as an off-white solid.

Aufarbeitung

  1. concentrationconcentrated
  2. customthe crude residue was purified by flash chromatography (elution with 50% ethyl acetate/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-67496c04989840a9921184ec86f9958e
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06645968B2

Notizen zur Reaktion

Wird geladen…