Sodium hydride → 2-(1-Methyl-3-pyrrolidinyloxy)-5-nitrobenzamide

HRID 4796

Reaktionsgleichung

Reaktionsgleichung von HRID 4796
[H-].[Na+].Cl[C:4]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7].[CH3:16][N:17]1[CH2:21][CH2:20][CH:19](CS([O-])(=O)=O)[CH2:18]1.S([O-])(=O)(=[O:29])C>CN(C)C=O>[CH3:16][N:17]1[CH2:21][CH2:20][CH:19]([O:29][C:4]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:5]=2[C:6]([NH2:8])=[O:7])[CH2:18]1

Komponenten

6

Edukt 4

HCID 24758Sodium hydride2×HCID 85257MethanesulfonateHCID 2865622-Chloro-5-nitrobenzamideHCID 131714710N-methyl-3-pyrrolidinylmesylate2×

Produkt 1

HCID 137262892-(1-Methyl-3-pyrrolidinyloxy)-5-nitrobenzamideAusbeute 12 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel3×

Versuchsvorschrift

To a cooled suspension of sodium hydride (2.42 g of 60% content 0.06 mole) in 50 ml of dimethylformamide under nitrogen was added dropwise a solution of 10 g (0.055 mole) of 2-chloro-5-nitrobenzamide in 20 ml dimethylformamide. The suspension was stirred at room temperature for 1 hr and heated to 60° C. at which time 9.9 g (0.055 mole) of N-methyl-3-pyrrolidinylmesylate (freshly prepared) in 10 ml of dimethylformamide was added. The reaction mixture was heated to 135° C. for 24 hr. Since little product was observed, 9.9 g (0.055 mole) addition N-methyl-3-pyrrolidinylmesylate and 1.21 g (60% in oil, 0.03 mole) of sodium hydride was added. Heating was continued for 24 hr. Another 4 equivalents of the above mesylate was added after cooling the reaction mixture to 100° C. The reaction mixture was maintained at 100° C. for 24 hr. The dimethylformamide was removed by rotary evaporation at 60° C., 0.5 mm Hg. The residue was taken up in 400 ml of methylene chloride and washed with 3×200 ml of 1N sodium hydroxide and 2×200 ml water. The organic layer was extracted with 3×200 ml of 1N hydrochloric acid. The aqueous extracts were combined and washed with ~200 ml chloroform. The aqueous layer was made basic with concentrated sodium hydroxide and extracted with 2×300 ml of methylene chloride. The organic extracts were combined, dried over sodium sulfate, filtered, and concentrated by rotary evaporation. The residue was crystallized from toluene to give 1.7 g (12%) of crude crystals. One recrystallization from toluene afforded light beige crystals, m.p. 215°-10° C.

Aufarbeitung

  1. additionwas added
  2. temperatureThe reaction mixture was heated to 135° C. for 24 hr
  3. additionwas added
  4. temperatureHeating
  5. waitwas continued for 24 hr
  6. temperatureafter cooling the reaction mixture to 100° C
  7. temperatureThe reaction mixture was maintained at 100° C. for 24 hr
  8. customThe dimethylformamide was removed by rotary evaporation at 60° C.
  9. washwashed with 3×200 ml of 1N sodium hydroxide and 2×200 ml water
  10. extractionThe organic layer was extracted with 3×200 ml of 1N hydrochloric acid
  11. washwashed with ~200 ml chloroform
  12. extractionextracted with 2×300 ml of methylene chloride
  13. dry with materialdried over sodium sulfate
  14. filtrationfiltered
  15. concentrationconcentrated by rotary evaporation
  16. customThe residue was crystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-ade44fe67a2945baad793a7536771fc1
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04727152

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