Ethanol → Ethyl 6-Aminonicotinate

HRID 479733

Reaktionsgleichung

Reaktionsgleichung von HRID 479733
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11](O)[CH3:12]>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:11][CH3:12])=[O:7])=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 702EthanolHCID 184966-Aminonicotinic acid

Produkt 1

HCID 235927Ethyl 6-Aminonicotinate

Versuchsvorschrift

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

Aufarbeitung

  1. customwas bubbled in dry hydrochloric acid at 0° C.
  2. temperaturethe solution was refluxed until all the solids
  3. dissolutiondissolved
  4. customThe solvents were removed under reduced pressure
  5. dissolutionthe residue dissolved in ethyl acetate
  6. washwashed with saturated sodium bicarbonate, brine
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-16a0a4e9bd2244cdb60a968f4ae8997f
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06646010B2

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