1-Fluoro-3-nitrobenzene → 1-Methyl-4-(3-nitrophenyl)piperazine

HRID 479994

Reaktionsgleichung

Reaktionsgleichung von HRID 479994
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[N+:8]([C:4]1[CH:3]=[C:2]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

Komponenten

3

Edukt 2

HCID 98231-Fluoro-3-nitrobenzeneHCID 531671-Methylpiperazine

Produkt 1

HCID 121521611-Methyl-4-(3-nitrophenyl)piperazine

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 3-fluoronitrobenzene (20 ml; 0.19 mol) and 1-methylpiperazine (40 ml; 0.36 mol) was heated to 120° C. for a week. The cooled mixture was purified by column-chromatography on silica gel using a mixture of ethyl acetate and methanol (9:1 v/1) as the eluent. Yield: 33 g (79%).

Aufarbeitung

  1. customThe cooled mixture was purified by column-chromatography on silica gel using
  2. additiona mixture of ethyl acetate and methanol (9:1 v/1) as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-f39715c2662d41ddbf33a553ad0a848e
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06649609B2

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