Water → Ethyl 4-(3-(4-acetyl-1-piperazinyl)-phenyl)-amino-6-fluoro-3-nitrobenzoate

https://huagongshe.com/de/reaction/480002

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Water	HCID 962	—
Edukt	Triethylamine	HCID 8471	—
Edukt	1-[4-(3-Aminophenyl)piperazin-1-yl]ethan-1-one	HCID 11117539	—
Edukt	Ethyl 2,4-difluoro-5-nitrobenzoate	HCID 22330120	—
Lösungsmittel	N-methyl-2-pyrrolidone	HCID 13387	—
Produkt	Ethyl 4-(3-(4-acetyl-1-piperazinyl)-phenyl)-amino-6-fluoro-3-nitrobenzoate	HCID 86592319	—

Reaktionsbedingungen

Temperatur	80 °C

Reaktionsschritte

A mixture of ethyl 2,4difluoro-5-nitrobenzoate (22) (1.0 g; 4.33 mmol), 4f (0.95 g; 4.33 mmol) and triethylamine (0.6 ml; 0.33 mmol) in anhydrous NMP (10 ml) was heated to 80° C. for one hour. The cooled mixture was poured into water and extracted with ethyl acetate. The organic extract was dried over magnesium sulphate, concentrated under reduced pressure and purified by column-chromatography on silica gel using ethyl acetate as the eluent. Yield: 1.53 g (82%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06649609B2
Quelldatensatz	uspto-grants-2003_11
ORD ID	ord-f60e53fbf16d4216930254366e7b9374
Quellennotiz	uspto-grants-2003_11