Acetone → 4-Amino-2-chlorobenzoic acid

HRID 48006

Reaktionsgleichung

Reaktionsgleichung von HRID 48006
[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H].CC(C)=O>C(O)C.[C].[Pd]>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([Cl:1])[CH:10]=1

Komponenten

6

Edukt 3

HCID 180AcetoneHCID 74482-Chloro-4-nitrobenzoic acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 171544-Amino-2-chlorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (250 mL) was dissolved 100 g (F.W. 201.57, 496 mmol) of 2-chloro-4-nitrobenzoic acid (1) and after replacing with argon, a 10% palladium carbon catalyst (4.0+1.5 g) was added thereto. After replacing with hydrogen, the mixture was stirred at room temperature for 72 hours. The formed crystal was dissolved with acetone and filtered to remove the catalyst. The solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2).

Aufarbeitung

  1. filtrationfiltered
  2. customto remove the catalyst
  3. distillationThe solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2)

Quellen und Nachweise

ORD-Eintrag
ord-1a0fb14af5eb4c08bc790f0d9076e4d8
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06700013B2

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