Ethanol → HCID 3045156, Verbindung

HRID 480422Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 480422
[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](=[O:5])[CH3:4].[N:8]1[CH:13]=[CH:12][C:11]([CH:14]=O)=[CH:10][CH:9]=1.C(O)C.[OH-].[Na+]>ClCCl>[C:2]([C:3](=[O:5])[CH:4]=[CH:14][C:11]1[CH:12]=[CH:13][N:8]=[CH:9][CH:10]=1)([CH3:7])([CH3:6])[CH3:1]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 6416PinacoloneHCID 133894-PyridinecarboxaldehydeHCID 14798Sodium Hydroxide

Produkt 1

HCID 3045156HCID 3045156, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 3,3-dimethyl-2-butanone (2.5 ml, 20.0 mmol), 4-pyridinecarboxaldehyde (2.15 ml, 22.3 mmol), ethanol (7.6 ml), and 4.5% aqueous sodium hydroxide (4.6 ml) was kept at room temperature for 12 h. It was diluted with dichloromethane, washed with aqueous hydrochloric acid and water, dried and evaporated. Subsequent column chromatography (hexane-ethyl acetate=3:1) provided the title compound. MS (m/z): 190.4 (M+H)+; C12H15NO requir. 189.3.

Aufarbeitung

  1. washwashed with aqueous hydrochloric acid and water
  2. customdried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-36b04c5defaf4828b8bfba1948e3b238
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06649604B2

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