Tetrahydrofuran → 1-(1H-Imidazol-4-yl)-1-(naphtho[2,1-b]furan-7-yl)-2-methyl-1-propanol

Temperatur

0 °C

Iodomethyl (0.05 mL) was added to mixture THF (5 mL) and magnesium (turnings, 0.719 g) with stirring. 7-bromonaphtho[2,1-b]furan (6.09 g) was added and the mixture was refluxed for 2 h. The resulting mixture was cooled to 0° C. and a solution of 4-formyl-1-trityl-1H-imidazole (4.71 g) in THF (40 mL) was added. The mixture was stirred at room temperature for 1 h and aq. ammonium chloride was added. The mixture was extracted with ethyl acetate, dried and concentrated. The residue was chromatographed on silica gel (eluent; hexane:ethyl acetate=2:1→1:2) to give the titled compound (2.30 g) as a colorless solid.

1. temperaturethe mixture was refluxed for 2 h
2. stirringThe mixture was stirred at room temperature for 1 h
3. extractionThe mixture was extracted with ethyl acetate
4. customdried
5. concentrationconcentrated
6. customThe residue was chromatographed on silica gel (eluent; hexane:ethyl acetate=2:1→1:2)

ORD-Eintrag

ord-d04ce16a99e44ef1b3727f730ae8150f

Quelldatensatz

uspto-grants-2003_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06649643B1