3-cyclopropyl-1H-pyrazol-5-amine → HCID 178420515, Verbindung

HRID 480597

Reaktionsgleichung

Reaktionsgleichung von HRID 480597
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[NH2:20][C:21]1[CH:25]=[C:24]([CH:26]2[CH2:28][CH2:27]2)[NH:23][N:22]=1>C1COCC1>[CH:26]1([C:24]2[CH:25]=[C:21]([NH:20][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[N:5]=[C:4]([CH2:12][O:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:3]=3)[NH:22][N:23]=2)[CH2:28][CH2:27]1

Komponenten

4

Edukt 2

HCID 27580143-cyclopropyl-1H-pyrazol-5-amineHCID 219910934-Chloro-2-phenoxymethylquinazoline

Produkt 1

HCID 178420515HCID 178420515, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

To a solution of the above 4-chloro-2-phenoxymethylquinazoline (0.5 g, 1.85 mmol) in THF (30 mL) is added 3-amino-5-cyclopropylpyrazole (0.47 g, 3.69 mmol) and the reaction mixture is heated at 65° C. for 24 hours. Solvent is evaporated and ethanol is added. A white solid forms and is collected by filtration and dried under vacuum to give (5-cyclopropyl-2H-pyrazol-3-yl)-(2-phenoxymethyl-quinazolin-4-yl)-amine.

Aufarbeitung

  1. customSolvent is evaporated
  2. additionethanol is added
  3. filtrationA white solid forms and is collected by filtration
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e804edbac68246a886d97f64747c325c
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06653300B2

Verknüpfte Notizen

Wird geladen…