HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 480608Erstellt: 23. Oktober 2026
Sodium Iodide → [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine
https://huagongshe.com/de/reaction/480608
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Iodide | HCID 5238 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| Edukt | 4,6-Dichloro-2[[(4-methoxyphenyl)methyl]thio]pyrimidine | HCID 13413724 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine | HCID 178419077 | — |
Reaktionsschritte
To a solution of above-prepared 4,6-dichloro-2-(4-methoxy-benzylsulfanyl)-pyrimidine (915 mg, 3.04 mmol) and 3-amino-5-methylpyrazole (310 mg, 3.19 mmol) in BuOH (20 mL) is added diisopropylethylamine (0.56 mL, 3.19 mmol) followed by sodium iodide (455 mg, 3.04 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US06653300B2 |
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| Quelldatensatz | uspto-grants-2003_11 |
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| ORD ID | ord-a963d47eb7884ecbb6832fc6d11cb7fa |
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| Quellennotiz | uspto-grants-2003_11 |
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