4-Methyl-1-pentanol → N-(3,4-dichlorophenyl)alanine 4-methylpentyl Ester

HRID 480844

Reaktionsgleichung

Reaktionsgleichung von HRID 480844
[CH3:1][O:2][C:3](=[O:15])[C@H:4]([CH3:14])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1.[CH3:16][CH:17]([CH3:22])[CH2:18][CH2:19]CO>>[CH3:16][CH:17]([CH3:22])[CH2:18][CH2:19][CH2:1][O:2][C:3](=[O:15])[C@H:4]([CH3:14])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1

Komponenten

3

Edukt 2

HCID 122964-Methyl-1-pentanolHCID 54289412N-(3,4-dichlorophenyl)alanine Methyl Ester

Produkt 1

HCID 53799568N-(3,4-dichlorophenyl)alanine 4-methylpentyl Ester

Versuchsvorschrift

Following transesterification General Procedure AB above and using N-(3,4-dichlorophenyl)alanine methyl ester (from Example A9 above) and 4-methylpentanol (Aldrich), the title compound was prepared as an oil. The reaction was monitored by silica gel tlc (Rf=0.70 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Aufarbeitung

  1. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-0a28d8ff71254311bfdf68f1d6dc13a2
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06653303B1

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