3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

HRID 480910

Reaktionsgleichung

Reaktionsgleichung von HRID 480910
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH:14]([CH3:16])[CH3:15]

Komponenten

3

Edukt 2

HCID 1454243,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Produkt 1

HCID 22894975N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

Versuchsvorschrift

Following General Procedure BI above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Quellen und Nachweise

ORD-Eintrag
ord-5ad1d7312f1749ccae750cd4c2b9fb7b
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06653303B1

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