Tetramethoxysilane → HCID 178503003, Verbindung

HRID 48096

Reaktionsgleichung

Reaktionsgleichung von HRID 48096
[Mg].[F:2][C:3]([F:27])([F:26])[O:4][C:5]1[CH:10]=[CH:9][C:8]([C@H:11]2[CH2:16][CH2:15][C@H:14]([C@H:17]3[CH2:22][CH2:21][C@H:20]([CH2:23][CH2:24]Cl)[CH2:19][CH2:18]3)[CH2:13][CH2:12]2)=[CH:7][CH:6]=1.[CH3:28][O:29][Si:30](OC)([O:33][CH3:34])[O:31][CH3:32]>C1COCC1>[F:2][C:3]([F:27])([F:26])[O:4][C:5]1[CH:10]=[CH:9][C:8]([C@H:11]2[CH2:16][CH2:15][C@H:14]([C@H:17]3[CH2:22][CH2:21][C@H:20]([CH2:23][CH2:24][Si:30]([O:33][CH3:34])([O:31][CH3:32])[O:29][CH3:28])[CH2:19][CH2:18]3)[CH2:13][CH2:12]2)=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 12682TetramethoxysilaneHCID 5462224MagnesiumHCID 178506380HCID 178506380, Verbindung

Produkt 1

HCID 178503003HCID 178503003, VerbindungAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A Grignard reagent was prepared from 100 ml of THF, magnesium (120 mmole) and 1-trifluoromethoxy-4-(trans-4-(trans-4-chloroethylcyclohexyl)cyclohexyl)benzene (100 mmole) under nitrogen atmosphere. A THF 100 ml solution of tetramethoxysilane (150 mmole) was heated to 65° C., and the Grignard reagent was added dropwise thereto. The solution was stirred at the same temperature for 2 hours, and after left standing for cooling, the reaction mixture was filtered. The solvent was distilled off, and then 1-trifluoromethoxy-4-(trans-4-(trans-4-trimethoxysilylethylcyclohexyl)cyclohexyl)benzene (57 mmole) was obtained by distillation under reduced pressure.

Aufarbeitung

  1. waitafter left standing
  2. temperaturefor cooling
  3. filtrationthe reaction mixture was filtered
  4. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-c5317193ef2e4833bc7f47c236f2fa9b
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703083B2

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