Potassium Hydroxide → 6-Benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic Acid

HRID 48108

Reaktionsgleichung

Reaktionsgleichung von HRID 48108
C([O:8][C:9]([CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=2)[CH2:12]1)=[O:10])C1C=CC=CC=1.[OH-].[K+]>O.C(O)C>[CH2:22]([O:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[CH2:12][CH:11]([C:9]([OH:10])=[O:8])[CH2:20][CH2:19]2)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 189601346-Benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic Acid Benzyl Ester

Produkt 1

HCID 190699736-Benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic AcidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

A solution of 6-benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid benzyl ester (30) (1 equi.) and potassium hydroxide (3.5 equi.) in water-ethanol (1:1) (25 mL/mmole) was stirred at 80 C temperature for 2 h, cooled to room temperature, and quenched with hydrochloric acid (5%), the resulting white solid was filtered, washed with water, and dried under vacuum to give 6-benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (31) as a white solid (95%).

Aufarbeitung

  1. customquenched with hydrochloric acid (5%)
  2. filtrationthe resulting white solid was filtered
  3. washwashed with water
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-37916f1e508f4919b9f142becd1a9cca
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703082B1

Verknüpfte Notizen

Wird geladen…