Potassium Hydroxide → 4-(Benzyloxy)benzoic acid

HRID 48116

Reaktionsgleichung

Reaktionsgleichung von HRID 48116
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:6][CH:5]=1.[OH-].[K+]>O.C(O)C>[CH2:11]([O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:18])=[O:2])=[CH:9][CH:8]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 299810Methyl 4-(benzyloxy)benzoate

Produkt 1

HCID 738804-(Benzyloxy)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

A solution 4-benzyloxy-benzoic acid methyl ester (3) (1 equi.) and potassium hydroxide (3.5 equi.) in water-ethanol (1:1) (25 mL/mmole) was stirred at 80 C temperature for 2 h., cooled to room temperature, quenched with hydrochloric acid (5%). The resulting white solid was filtered, washed with water, and dried under vacuum to give 4-benzyloxy-benzoic acid (4)) as a white solid (80%).

Aufarbeitung

  1. customquenched with hydrochloric acid (5%)
  2. filtrationThe resulting white solid was filtered
  3. washwashed with water
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f087fce06c8c4d12b0590aeec6bca168
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703082B1

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